LOCUS NC_001489 7478 bp ss-RNA linear VRL 08-DEC-2008 DEFINITION Hepatitis A virus, complete genome. ACCESSION NC_001489 VERSION NC_001489.1 GI:9626732 DBLINK BioProject: PRJNA15308 KEYWORDS RefSeq. SOURCE Hepatitis A virus ORGANISM Hepatitis A virus Viruses; ssRNA positive-strand viruses, no DNA stage; Picornavirales; Picornaviridae; Hepatovirus. REFERENCE 1 (bases 1 to 7478) AUTHORS Cohen,J.I., Ticehurst,J.R., Purcell,R.H., Buckler-White,A. and Baroudy,B.M. TITLE Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses JOURNAL J. Virol. 61 (1), 50-59 (1987) PUBMED 3023706 REFERENCE 2 (bases 1 to 7478) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (09-SEP-2004) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M14707. There are polypyrimidine tracts at positions 98 to 137 and 712 to 720. This sequence supersedes several previously published partial sequences of the hepatitis A virus wild type virus. These partial genomic sequences are found under accession numbers K00386, M14114 and M14115. Draft entry and computer-readable copy of sequence in [1] kindly provided by J.I.Cohen, 05-AUG-1987. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..7478 /organism="Hepatitis A virus" /mol_type="genomic RNA" /db_xref="taxon:12092" gene 1..7478 /locus_tag="HAVgs1" /db_xref="GeneID:1493917" misc_RNA 1..7478 /locus_tag="HAVgs1" /note="hepatitis A viral genome" /db_xref="GeneID:1493917" gene 735..7418 /locus_tag="HAVgp1" /db_xref="GeneID:1493918" CDS 735..7418 /locus_tag="HAVgp1" /note="polyprotein a (alt.)" /codon_start=1 /product="hypothetical protein" /protein_id="NP_041007.1" /db_xref="GI:9626733" /db_xref="GeneID:1493918" /translation="MNMSRQGIFQTVGSGLDHILSLADIEEEQMIQSVDRTAVTGASY FTSVDQSSVHTAEVGSHQVEPLRTSVDKPGSKKTQGEKFFLIHSADWLTTHALFHEVA KLDVVKLLYNEQFAVQGLLRYHTYARFGIEIQVQINPTPFQQGGLICAMVPGDQSYGS IASLTVYPHGLLNCNINNVVRIKVPFIYTRGAYHFKDPQYPVWELTIRVWSELNIGTG TSAYTSLNVLARFTDLELHGLTPLSTQMMRNEFRVSTTENVVNLSNYEDARAKMSFAL DQEDWKSDPSQGGGIKITHFTTWTSIPTLAAQFPFNASDSVGQQIKVIPVDPYFFQMT NTNPDQKCITALASICQMFCFWRGDLVFDFQVFPTKYHSGRLLFCFVPGNELIDVSGI TLKQATTAPCAVMDITGVQSTLRFRVPWISDTPYRVNRYTKSAHQKGEYTAIGKLIVY CYNRLTSPSNVASHVRVNVYLSAINLECFAPLYHAMDVTTQVGDDSGGFSTTVSTEQN VPDPQVGITTMKDLKGKANRGKMDVSGVQAPVGAITTIEDPVLAKKVPETFPELKPGE SRHTSDHMSIYKFMGRSHFLCTFTFNSNNKEYTFPITLSSTSNPPHGLPSTLRWFFNL FQLYRGPLDLTIIITGATDVDGMAWFTPVGLAVDTPWVEKESALSIDYKTALGAVRFN TRRTGNIQIRLPWYSYLYAVSGALDGLGDKTDSTFGLVSIQIANYNHSDEYLSFSCYL SVTEQSEFYFPRAPLNSNAMLSTESMMSRIAAGDLESSVDDPRSEEDKRFESHIECRK PYKELRLEVGKQRLKYAQEELSNEVLPPPRKMKGLFSQAKISLFYTEEHEIMKFSWRG VTADTRALRRFGFSLAAGRSVWTLEMDAGVLTGRLIRLNDEKWTEMKDDKIVSLIEKF TSNKYWSKVNFPHGMLDLEEIAANSKDFPNMSETDLCFLLHWLNPKKINLADRMLGLS GVQEIKEQGVGLIAECRTFLDSIAGTLKSMMFGFHHSVTVEIINTVLCFVKSGILLYV IQQLNQDEHSHIIGLLRVMNYADIGCSVISCGKVFSKMLETVFNWQMDSRMMELRTQS FSNWLRDICSGITIFKNFKDAIYWLYTKLKDFYEVNYGKKKDILNILKDNQQKIEKAI EEADEFCILQIQDVEKFEQYQKGVDLIQKLRTVHSMAQVDPNLMVHLSPLRDCIARVH QKLKNLGSINQAMVTRCEPVVCYLYGKRGGGKSLTSIALATKICKHYGVEPEKNIYTK PVASDYWDGYSGQLVCIIDDIGQNTTDEDWSDFCQLVSGCPMRLNMASLEEKGRHFSS PFIIATSNWSNPSPKTVYVKEAIDRRLHFKVEVKPASFFKNPHNDMLNVNLAKTNDAI KDMSCVDLIMDGHNVSLMDLLSSLVMTVEIRKQNMTEFMELWSQGISDDDNDSAVAEF FQSFPSGEPSNSKLSGFFQSVTNHKWVAVGAAVGILGVLVGGWFVYKHFSRKEEEPIP AEGVYHGVTKPKQVIKLDADPVESQSTLEIAGLVRKNLVQFGVGEKNGCVRWVMNALG VKDDWLLVPSHAYKFEKDYEMMEFYFNRGGTYYSISAGNVVIQSLDVGFQDVVLMKVP TIPKFRDITQHFIKKGDVPRALNRLATLVTTVNGTPMLISEGPLKMEEKATYVHKKND GTTVDLTVDQAWRGKGEGLPGMCGGALVSSNQSIQNAILGIHVAGGNSILVAKLVTQE MFQNIDKKIESQRIMKVEFTQCSMNVVSKTLFRKSPIYHHIDKTMINFPAAMPFSKAE IDPMAVMLSKYSLPIVEEPEDYKEASIFYQNKIVGKTQLVDDFLDLDMAITGAPGIDA INMDSSPGFPYVQEKLTKRDLIWLDENGLLLGVHPRLAQRILFNTVMMENCSDLDVVF TTCPKDELRPLEKVLESKTRAIDACPLDYSILCRMYWGPAISYFHLNPGFHTGVAIGI DPDRQWDELFKTMIRFGDVGLDLDFSAFDASLSPFMIREAGRIMSELSGTPSHFGTAL INTIIYSKHLLYNCCYHVCGSMPSGSPCTALLNSIINNVNLYYVFSKIFGKSPVFFCQ ALKILCYGDDVLIVFSRDVQIDNLDLIGQKIVDEFKKLGMTATSADKNVPQLKPVSEL TFLKRSFNLVEDRIRPAISEKTIWSLIAWQRSNAEFEQNLENAQWFAFMHGYEFYQKF YYFVQSCLEKEMIEYRLKSYDWWRMRFYDQCFICDLS" mat_peptide 735..803 /locus_tag="HAVgp1" /product="1A VP4a mature peptide (alt.)" /protein_id="NP_740548.1" /db_xref="GI:25121593" misc_feature 981..1463 /locus_tag="HAVgp1" /note="Picornavirus capsid protein domain_like. Picornaviruses are non-enveloped plus-strand ssRNA animal viruses with icosahedral capsids composed of 60 copies each of 4 virus encoded proteins; alignment includes picornaviridae, like poliovirus, hepatitis A...; Region: rhv_like; cd00205" /db_xref="CDD:119412" misc_feature order(1050..1052,1125..1127,1131..1133,1137..1139, 1185..1187,1242..1244,1338..1340,1419..1421) /locus_tag="HAVgp1" /note="drug-binding pocket [chemical binding]; other site" /db_xref="CDD:119412" misc_feature 1632..2177 /locus_tag="HAVgp1" /note="Picornavirus capsid protein domain_like. Picornaviruses are non-enveloped plus-strand ssRNA animal viruses with icosahedral capsids composed of 60 copies each of 4 virus encoded proteins; alignment includes picornaviridae, like poliovirus, hepatitis A...; Region: rhv_like; cd00205" /db_xref="CDD:119412" misc_feature order(1716..1718,1812..1814,1818..1820,1824..1826, 1872..1874,1941..1943,2013..2015,2064..2066,2145..2147) /locus_tag="HAVgp1" /note="drug-binding pocket [chemical binding]; other site" /db_xref="CDD:119412" misc_feature 2469..2999 /locus_tag="HAVgp1" /note="Picornavirus capsid protein domain_like. Picornaviruses are non-enveloped plus-strand ssRNA animal viruses with icosahedral capsids composed of 60 copies each of 4 virus encoded proteins; alignment includes picornaviridae, like poliovirus, hepatitis A...; Region: rhv_like; cl13999" /db_xref="CDD:265416" misc_feature order(2550..2552,2628..2630,2634..2636,2640..2642, 2682..2684,2769..2771,2838..2840,2883..2885,2952..2954) /locus_tag="HAVgp1" /note="drug-binding pocket [chemical binding]; other site" /db_xref="CDD:119412" misc_feature 2934..3245 /locus_tag="HAVgp1" /note="Protein of unknown function (DUF3840); Region: DUF3840; pfam12944" /db_xref="CDD:193417" misc_feature 4410..4718 /locus_tag="HAVgp1" /note="RNA helicase; Region: RNA_helicase; pfam00910" /db_xref="CDD:250218" misc_feature 5313..5876 /locus_tag="HAVgp1" /note="3C cysteine protease (picornain 3C); Region: Peptidase_C3; pfam00548" /db_xref="CDD:249949" misc_feature 6423..7220 /locus_tag="HAVgp1" /note="RNA_dep_RNAP: RNA-dependent RNA polymerase (RdRp) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage. RdRp catalyzes synthesis of the RNA strand complementary to a given RNA template. RdRps of many viruses are...; Region: RNA_dep_RNAP; cd01699" /db_xref="CDD:238843" misc_feature order(6678..6695,6852..6857,6975..6977,6981..6986, 7137..7142) /locus_tag="HAVgp1" /note="active site" /db_xref="CDD:238843" misc_feature order(6678..6683,6981..6986) /locus_tag="HAVgp1" /note="metal ion binding site [ion binding]; other site" /db_xref="CDD:238843" misc_feature 6855..6857 /locus_tag="HAVgp1" /note="putative nucleic acid binding site [nucleotide binding]; other site" /db_xref="CDD:238843" gene 741..7418 /locus_tag="HAVgp2" /db_xref="GeneID:1493919" CDS 741..7418 /locus_tag="HAVgp2" /note="polyprotein b (alt.)" /codon_start=1 /product="hypothetical protein" /protein_id="NP_041008.1" /db_xref="GI:9626734" /db_xref="GeneID:1493919" /translation="MSRQGIFQTVGSGLDHILSLADIEEEQMIQSVDRTAVTGASYFT SVDQSSVHTAEVGSHQVEPLRTSVDKPGSKKTQGEKFFLIHSADWLTTHALFHEVAKL DVVKLLYNEQFAVQGLLRYHTYARFGIEIQVQINPTPFQQGGLICAMVPGDQSYGSIA SLTVYPHGLLNCNINNVVRIKVPFIYTRGAYHFKDPQYPVWELTIRVWSELNIGTGTS AYTSLNVLARFTDLELHGLTPLSTQMMRNEFRVSTTENVVNLSNYEDARAKMSFALDQ EDWKSDPSQGGGIKITHFTTWTSIPTLAAQFPFNASDSVGQQIKVIPVDPYFFQMTNT NPDQKCITALASICQMFCFWRGDLVFDFQVFPTKYHSGRLLFCFVPGNELIDVSGITL KQATTAPCAVMDITGVQSTLRFRVPWISDTPYRVNRYTKSAHQKGEYTAIGKLIVYCY NRLTSPSNVASHVRVNVYLSAINLECFAPLYHAMDVTTQVGDDSGGFSTTVSTEQNVP DPQVGITTMKDLKGKANRGKMDVSGVQAPVGAITTIEDPVLAKKVPETFPELKPGESR HTSDHMSIYKFMGRSHFLCTFTFNSNNKEYTFPITLSSTSNPPHGLPSTLRWFFNLFQ LYRGPLDLTIIITGATDVDGMAWFTPVGLAVDTPWVEKESALSIDYKTALGAVRFNTR RTGNIQIRLPWYSYLYAVSGALDGLGDKTDSTFGLVSIQIANYNHSDEYLSFSCYLSV TEQSEFYFPRAPLNSNAMLSTESMMSRIAAGDLESSVDDPRSEEDKRFESHIECRKPY KELRLEVGKQRLKYAQEELSNEVLPPPRKMKGLFSQAKISLFYTEEHEIMKFSWRGVT ADTRALRRFGFSLAAGRSVWTLEMDAGVLTGRLIRLNDEKWTEMKDDKIVSLIEKFTS NKYWSKVNFPHGMLDLEEIAANSKDFPNMSETDLCFLLHWLNPKKINLADRMLGLSGV QEIKEQGVGLIAECRTFLDSIAGTLKSMMFGFHHSVTVEIINTVLCFVKSGILLYVIQ QLNQDEHSHIIGLLRVMNYADIGCSVISCGKVFSKMLETVFNWQMDSRMMELRTQSFS NWLRDICSGITIFKNFKDAIYWLYTKLKDFYEVNYGKKKDILNILKDNQQKIEKAIEE ADEFCILQIQDVEKFEQYQKGVDLIQKLRTVHSMAQVDPNLMVHLSPLRDCIARVHQK LKNLGSINQAMVTRCEPVVCYLYGKRGGGKSLTSIALATKICKHYGVEPEKNIYTKPV ASDYWDGYSGQLVCIIDDIGQNTTDEDWSDFCQLVSGCPMRLNMASLEEKGRHFSSPF IIATSNWSNPSPKTVYVKEAIDRRLHFKVEVKPASFFKNPHNDMLNVNLAKTNDAIKD MSCVDLIMDGHNVSLMDLLSSLVMTVEIRKQNMTEFMELWSQGISDDDNDSAVAEFFQ SFPSGEPSNSKLSGFFQSVTNHKWVAVGAAVGILGVLVGGWFVYKHFSRKEEEPIPAE GVYHGVTKPKQVIKLDADPVESQSTLEIAGLVRKNLVQFGVGEKNGCVRWVMNALGVK DDWLLVPSHAYKFEKDYEMMEFYFNRGGTYYSISAGNVVIQSLDVGFQDVVLMKVPTI PKFRDITQHFIKKGDVPRALNRLATLVTTVNGTPMLISEGPLKMEEKATYVHKKNDGT TVDLTVDQAWRGKGEGLPGMCGGALVSSNQSIQNAILGIHVAGGNSILVAKLVTQEMF QNIDKKIESQRIMKVEFTQCSMNVVSKTLFRKSPIYHHIDKTMINFPAAMPFSKAEID PMAVMLSKYSLPIVEEPEDYKEASIFYQNKIVGKTQLVDDFLDLDMAITGAPGIDAIN MDSSPGFPYVQEKLTKRDLIWLDENGLLLGVHPRLAQRILFNTVMMENCSDLDVVFTT CPKDELRPLEKVLESKTRAIDACPLDYSILCRMYWGPAISYFHLNPGFHTGVAIGIDP DRQWDELFKTMIRFGDVGLDLDFSAFDASLSPFMIREAGRIMSELSGTPSHFGTALIN TIIYSKHLLYNCCYHVCGSMPSGSPCTALLNSIINNVNLYYVFSKIFGKSPVFFCQAL KILCYGDDVLIVFSRDVQIDNLDLIGQKIVDEFKKLGMTATSADKNVPQLKPVSELTF LKRSFNLVEDRIRPAISEKTIWSLIAWQRSNAEFEQNLENAQWFAFMHGYEFYQKFYY FVQSCLEKEMIEYRLKSYDWWRMRFYDQCFICDLS" mat_peptide 741..803 /locus_tag="HAVgp2" /product="1A VP4b mature peptide (alt.)" /protein_id="NP_740549.1" /db_xref="GI:25121594" mat_peptide 804..1469 /locus_tag="HAVgp2" /product="1B VP2 mature peptide" /protein_id="NP_740550.1" /db_xref="GI:25121595" misc_feature 981..1463 /locus_tag="HAVgp2" /note="Picornavirus capsid protein domain_like. Picornaviruses are non-enveloped plus-strand ssRNA animal viruses with icosahedral capsids composed of 60 copies each of 4 virus encoded proteins; alignment includes picornaviridae, like poliovirus, hepatitis A...; Region: rhv_like; cd00205" /db_xref="CDD:119412" misc_feature order(1050..1052,1125..1127,1131..1133,1137..1139, 1185..1187,1242..1244,1338..1340,1419..1421) /locus_tag="HAVgp2" /note="drug-binding pocket [chemical binding]; other site" /db_xref="CDD:119412" mat_peptide 1470..2207 /locus_tag="HAVgp2" /product="1C VP3 mature peptide" /protein_id="NP_740551.1" /db_xref="GI:25121596" misc_feature 1632..2177 /locus_tag="HAVgp2" /note="Picornavirus capsid protein domain_like. Picornaviruses are non-enveloped plus-strand ssRNA animal viruses with icosahedral capsids composed of 60 copies each of 4 virus encoded proteins; alignment includes picornaviridae, like poliovirus, hepatitis A...; Region: rhv_like; cd00205" /db_xref="CDD:119412" misc_feature order(1716..1718,1812..1814,1818..1820,1824..1826, 1872..1874,1941..1943,2013..2015,2064..2066,2145..2147) /locus_tag="HAVgp2" /note="drug-binding pocket [chemical binding]; other site" /db_xref="CDD:119412" mat_peptide 2208..3107 /locus_tag="HAVgp2" /product="1D VP1 mature peptide" /protein_id="NP_740552.1" /db_xref="GI:25121597" misc_feature 2469..2999 /locus_tag="HAVgp2" /note="Picornavirus capsid protein domain_like. Picornaviruses are non-enveloped plus-strand ssRNA animal viruses with icosahedral capsids composed of 60 copies each of 4 virus encoded proteins; alignment includes picornaviridae, like poliovirus, hepatitis A...; Region: rhv_like; cl13999" /db_xref="CDD:265416" misc_feature order(2550..2552,2628..2630,2634..2636,2640..2642, 2682..2684,2769..2771,2838..2840,2883..2885,2952..2954) /locus_tag="HAVgp2" /note="drug-binding pocket [chemical binding]; other site" /db_xref="CDD:119412" misc_feature 2934..3245 /locus_tag="HAVgp2" /note="Protein of unknown function (DUF3840); Region: DUF3840; pfam12944" /db_xref="CDD:193417" mat_peptide 3108..3674 /locus_tag="HAVgp2" /product="2A mature peptide" /note="Capsid assembly signal 2A is removed from the VP1-2A protein by a postassembly proteolytic event that presumably involves a host proteinase such as FXa; capsid assembly signal 2A" /protein_id="NP_740553.1" /db_xref="GI:25121598" mat_peptide 3675..3995 /locus_tag="HAVgp2" /product="2B mature peptide" /protein_id="NP_740554.1" /db_xref="GI:25121599" mat_peptide 3996..5000 /locus_tag="HAVgp2" /product="2C mature peptide" /protein_id="NP_740555.1" /db_xref="GI:25121600" misc_feature 4410..4718 /locus_tag="HAVgp2" /note="RNA helicase; Region: RNA_helicase; pfam00910" /db_xref="CDD:250218" mat_peptide 5001..5222 /locus_tag="HAVgp2" /product="3A mature peptide" /protein_id="NP_740556.1" /db_xref="GI:25121601" mat_peptide 5223..5291 /locus_tag="HAVgp2" /product="3B (VPg) mature peptide" /protein_id="NP_740557.1" /db_xref="GI:25121602" mat_peptide 5292..5948 /locus_tag="HAVgp2" /product="3C mature peptide" /protein_id="NP_740558.1" /db_xref="GI:25121603" misc_feature 5313..5876 /locus_tag="HAVgp2" /note="3C cysteine protease (picornain 3C); Region: Peptidase_C3; pfam00548" /db_xref="CDD:249949" mat_peptide 5949..7415 /locus_tag="HAVgp2" /product="3D mature peptide" /protein_id="NP_740559.1" /db_xref="GI:25121604" misc_feature 6423..7220 /locus_tag="HAVgp2" /note="RNA_dep_RNAP: RNA-dependent RNA polymerase (RdRp) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage. RdRp catalyzes synthesis of the RNA strand complementary to a given RNA template. RdRps of many viruses are...; Region: RNA_dep_RNAP; cd01699" /db_xref="CDD:238843" misc_feature order(6678..6695,6852..6857,6975..6977,6981..6986, 7137..7142) /locus_tag="HAVgp2" /note="active site" /db_xref="CDD:238843" misc_feature order(6678..6683,6981..6986) /locus_tag="HAVgp2" /note="metal ion binding site [ion binding]; other site" /db_xref="CDD:238843" misc_feature 6855..6857 /locus_tag="HAVgp2" /note="putative nucleic acid binding site [nucleotide binding]; other site" /db_xref="CDD:238843" variation 871 /locus_tag="HAVgp2" /note="c in pHAVlb39, t in pHAVlb113" variation 2196 /locus_tag="HAVgp2" /note="g in pHAVlb39, a in pHAVlb1307" variation 6216 /locus_tag="HAVgp2" /note="t in pHAVlb93, c in pHAVlb24" ORIGIN 1 ttcaagaggg gtctccggga atttccggag tccctcttgg aagtccatgg tgaggggact 61 tgatacctca ccgccgtttg cctaggctat aggctaaatt ttccctttcc cttttccctt 121 tcctattccc tttgttttgc ttgtaaatat taattcctgc aggttcaggg ttcttaaatc 181 tgtttctcta taagaacact catttttcac gctttctgtc ttctttcttc cagggctctc 241 cccttgccct aggctctggc cgttgcgccc ggcggggtca actccatgat tagcatggag 301 ctgtaggagt ctaaattggg gacacagatg tttggaacgt caccttgcag tgttaacttg 361 gctttcatga atctctttga tcttccacaa ggggtaggct acgggtgaaa cctcttaggc 421 taatacttct atgaagagat gccttggata gggtaacagc ggcggatatt ggtgagttgt 481 taagacaaaa accattcaac gccggaggac tgactctcat ccagtggatg cattgagtgg 541 attgactgtc agggctgtct ttaggcttaa ttccagacct ctctgtgctt agggcaaaca 601 tcatttggcc ttaaatggga ttctgtgaga ggggatccct ccattgacag ctggactgtt 661 ctttggggcc ttatgtggtg tttgcctctg aggtactcag gggcatttag gtttttcctc 721 attcttaaat aataatgaac atgtctagac aaggtatttt ccagactgtt gggagtggtc 781 ttgaccacat cctgtctttg gcagacattg aggaagagca aatgattcaa tcagttgata 841 ggactgcagt gactggtgct tcttatttta cttctgtgga tcaatcttca gttcatacag 901 ctgaggttgg atcacaccag gttgaacctt tgagaacctc tgttgataaa cccggttcaa 961 agaagactca gggagagaaa tttttcttga ttcattctgc agattggctt actacacatg 1021 ctcttttcca tgaagttgca aaattggatg tggtgaaatt attatacaat gagcagtttg 1081 ctgttcaagg gttgttgaga taccatacat atgcaagatt tggcattgaa attcaagttc 1141 agataaaccc tacacctttc caacaggggg gattgatctg tgctatggtt cctggtgacc 1201 agagctatgg ttctatagca tcattgactg tttatcctca tggtttgtta aattgcaata 1261 ttaacaatgt ggttagaata aaggttccat ttatttacac aagaggtgct taccacttta 1321 aagatccaca atacccagtt tgggaattga caattagagt ttggtcagaa ttaaatattg 1381 ggacaggaac ttcagcttat acttcactca atgttttagc tagatttaca gatttggagt 1441 tgcatggatt aactcctctt tctacacaaa tgatgagaaa tgaatttagg gtcagtacta 1501 ctgagaatgt ggtgaatctg tcaaattatg aagatgcaag agcaaagatg tcttttgctt 1561 tggatcagga agattggaaa tctgatccgt cccagggtgg tgggatcaaa attactcatt 1621 ttactacttg gacatctatt ccaactttgg ctgctcagtt tccatttaat gcttcagact 1681 cagttggtca acaaattaaa gttattccag ttgacccata ttttttccaa atgacaaata 1741 cgaatcctga ccaaaaatgt ataactgctt tggcttctat ttgtcagatg ttttgttttt 1801 ggagaggaga tcttgtcttt gattttcaag tttttcccac caaatatcat tcaggtagat 1861 tactgttttg ttttgttcct ggcaatgagc taatagatgt ttctggaatc acattaaagc 1921 aagcaactac tgctccttgt gcagtaatgg atattacagg agtgcagtca actttgagat 1981 ttcgtgttcc ctggatttct gacactcctt acagagtgaa caggtataca aagtcagcac 2041 atcagaaagg tgagtacact gccattggga agcttattgt gtattgttat aacagattga 2101 cctctccttc taacgttgct tcccatgtca gagtgaatgt ttatctttca gcaattaact 2161 tggaatgttt tgctcctctt tatcatgcta tggatgttac tacacaagtt ggagatgatt 2221 ctggaggttt ttcaacaaca gtttctacag aacagaatgt tccagatccc caagttggta 2281 taacaaccat gaaagatttg aaaggaaaag ctaacagagg gaaaatggat gtttcaggag 2341 tacaagcacc tgtgggagct atcacaacaa ttgaggatcc agttttagca aagaaagtac 2401 ctgagacatt tcctgaattg aaacctggag aatccagaca tacatcagat catatgtcca 2461 tctacaagtt tatgggaagg tctcatttct tgtgcacttt tacattcaat tcaaataata 2521 aagagtacac atttcctata accttgtctt caacctctaa tcctcctcat ggtttgccat 2581 caacactgag gtggtttttc aacttgtttc agttgtatag agggccttta gatctgacaa 2641 ttattattac aggagcaact gatgtagatg gcatggcctg gttcactcca gtaggtcttg 2701 ccgttgatac tccttgggta gagaaggagt cagctttgtc tattgactac aaaactgctc 2761 ttggagctgt cagatttaac acaaggagaa cagggaacat tcagattaga ttaccatggt 2821 attcttattt atatgctgtg tctggagcac tggatggttt gggtgacaag acagattcta 2881 catttggatt ggtttctatt cagattgcaa attacaatca ttctgatgaa tacttgtctt 2941 ttagttgtta tttgtctgtc acagaacaat cagagtttta ttttcccaga gctccattga 3001 actcaaatgc catgttatcc actgaatcaa tgatgagcag aattgcagct ggagacttgg 3061 agtcatcagt ggatgatcct agatcagagg aagataaaag atttgagagt catatagaat 3121 gcaggaagcc atataaagaa ctgagattag aagttgggaa acaaagactc aagtatgctc 3181 aggaagaatt gtcaaatgaa gtacttccac cccctaggaa aatgaaggga ctgttttcac 3241 aagccaaaat ttctcttttt tatactgagg agcatgaaat aatgaagttt tcctggagag 3301 gtgtgactgc tgatactaga gctttaagga ggtttggatt ctctttggcc gcaggcagaa 3361 gtgtgtggac tcttgaaatg gatgctgggg ttcttactgg gagactgatt agattgaatg 3421 atgagaaatg gacagaaatg aaggatgaca agattgtttc attgattgaa aagtttacaa 3481 gtaacaaata ttggtccaaa gtgaatttcc cacatgggat gttggatctt gaagaaattg 3541 ctgccaattc taaggatttt cctaacatgt ctgaaacgga tttgtgtttc ttgctgcatt 3601 ggttaaatcc aaagaaaatt aatttagcag atagaatgct tggattgtct ggagttcagg 3661 aaattaaaga acaaggtgtt ggattaatag cagagtgtag aactttctta gattctattg 3721 ctggaacttt aaaatctatg atgtttggat ttcatcattc tgtgactgtt gaaattataa 3781 acactgtgct ctgttttgtt aagagtggaa ttttgcttta tgtaatacaa caattgaatc 3841 aggatgaaca ttctcacata attggtttgt tgagagtcat gaattatgca gatattggtt 3901 gttcagttat ttcatgtggc aaagtttttt ccaaaatgct ggaaacagtc tttaattggc 3961 aaatggactc cagaatgatg gagttaagga ctcagagttt ttccaactgg ttaagagata 4021 tttgttctgg gatcaccatt tttaaaaact tcaaggatgc aatttattgg ctttatacaa 4081 aattaaagga cttttatgaa gtgaattatg gcaagaagaa ggacatttta aatattctta 4141 aagataacca acaaaaaata gagaaagcca ttgaggaagc cgatgaattt tgcattttgc 4201 aaatccaaga tgtggaaaaa tttgaacagt atcagaaagg ggttgacttg atacaaaaat 4261 tgagaactgt tcattcaatg gctcaggttg atccaaattt aatggttcat ttgtcacctt 4321 tgagagattg tatagcaaga gttcatcaga aacttaaaaa ccttggatct ataaatcagg 4381 caatggtaac gagatgtgag ccagttgttt gttatttata tggcaaaaga gggggaggaa 4441 agagcttaac atcaattgca ttggcaacca aaatttgtaa acattatggt gttgagcctg 4501 aaaagaatat ctatactaaa cctgtggctt cagattactg ggatggatat agtggacaat 4561 tagtttgcat cattgatgat attggccaaa acacaacaga tgaggattgg tcagattttt 4621 gtcagttagt gtcaggatgt ccaatgagat taaacatggc ctctcttgag gagaagggta 4681 ggcatttttc ttctcctttt ataatagcaa cttcaaattg gtcaaatcca agtccaaaaa 4741 cagtttatgt taaggaagca attgaccgca gactccattt caaggttgaa gttaaacctg 4801 cttcattttt caaaaatcct cacaatgata tgttgaatgt taatttagct aaaacaaatg 4861 atgcaatcaa agatatgtct tgtgttgatt tgataatgga tggacataat gtttcattga 4921 tggatttgct cagttcttta gtcatgacag ttgaaattag aaaacaaaac atgactgaat 4981 tcatggagtt gtggtctcag ggaatttcag atgatgataa tgatagtgca gtagctgagt 5041 ttttccagtc ttttccatct ggtgaaccat cgaactctaa attatctggc tttttccaat 5101 ctgttactaa tcacaagtgg gttgctgtgg gagctgcagt tggcattctt ggagtgctcg 5161 ttggaggatg gtttgtgtat aagcatttct cccgcaaaga ggaggaacca atcccagctg 5221 aaggggtata tcatggtgta actaagccca agcaagtgat taaattagat gcagatccag 5281 tagaatctca gtcaactttg gaaatagcag gactggttag gaagaacttg gttcagtttg 5341 gagttggaga gaagaatgga tgtgtgagat gggttatgaa tgccttggga gtgaaagatg 5401 attggctgct tgtgccttcc catgcttata aatttgagaa agattatgaa atgatggagt 5461 tttattttaa tagaggtgga acttactatt caatttcagc tggtaatgtt gttattcaat 5521 ctttggatgt gggattccag gatgttgttc tgatgaaggt tcctacaatt cctaagttta 5581 gagatattac tcagcatttt attaagaaag gggatgtgcc tagagctttg aatcgcctgg 5641 caacattagt gacaactgta aatggaaccc ctatgttaat ttctgagggc ccactaaaga 5701 tggaagagaa agctacttat gttcataaga aaaatgatgg tacaacagtt gatttaactg 5761 tggatcaggc atggagagga aaaggcgaag gtcttcctgg aatgtgtggt ggggccttgg 5821 tttcatcgaa tcaatctata cagaatgcaa tcttgggcat ccatgttgct ggaggaaatt 5881 caattcttgt tgcaaaattg gttactcaag aaatgttcca aaatattgat aagaaaattg 5941 aaagtcagag aattatgaaa gtggagttta ctcagtgttc aatgaatgtg gtctccaaaa 6001 cgctttttag aaagagtccc atttatcatc acattgataa aaccatgatt aattttcctg 6061 cagctatgcc cttttctaaa gctgaaattg atccaatggc tgtgatgtta tctaagtatt 6121 cattacctat tgtagaagaa ccagaggatt ataaagaggc ttcaattttt tatcaaaata 6181 aaatagtggg taagactcag ttagttgatg attttttaga tcttgatatg gccattacag 6241 gggccccagg aattgatgct atcaacatgg attcatctcc tggatttcct tatgtccagg 6301 agaagttgac caaaagagat ttaatttggt tggatgaaaa tggtttattg ctgggagttc 6361 atccaagatt ggctcagaga atcttattca atactgtcat gatggaaaat tgttctgatt 6421 tggatgttgt ttttacaacc tgtccaaaag atgaattgag accattagag aaagtgttgg 6481 aatcaaaaac aagagctatt gatgcttgtc ctctggatta ctcaattttg tgccgaatgt 6541 attggggtcc agctattagt tattttcatt tgaatccagg tttccataca ggtgttgcta 6601 ttggcataga tcctgataga cagtgggatg aattatttaa aacaatgata agattcggag 6661 atgttggtct tgatttagat ttctctgctt ttgatgctag tcttagtcca tttatgatta 6721 gagaagcagg tagaatcatg agtgaactat ctggaactcc atcccatttt ggcacagctc 6781 ttatcaatac tatcatttat tccaagcatt tgctgtataa ctgttgttac catgtctgtg 6841 gttcaatgcc ctctgggtct ccttgtacag ctttgctaaa ttcaattatt aataatgtca 6901 atttgtatta tgtgttttcc aagatatttg gaaagtctcc agttttcttt tgtcaggctt 6961 tgaagattct ctgttatgga gatgatgttt taatagtttt ctctcgagat gttcagattg 7021 ataatcttga tttgattgga caaaaaattg tagatgagtt taagaaactt ggcatgacag 7081 ctacttctgc tgacaagaat gtacctcagc tgaaaccagt ttcggaattg acttttctca 7141 aaagatcttt caatttggta gaggatagaa ttagacctgc aatttcggaa aaaacaattt 7201 ggtctttaat agcatggcag agaagtaacg ctgagtttga gcagaattta gaaaatgctc 7261 agtggtttgc ttttatgcat ggctatgagt tttatcagaa attttattat tttgttcagt 7321 cctgtttgga gaaagagatg atagaataca gacttaaatc ttatgattgg tggagaatga 7381 gattttatga ccagtgtttc atttgtgacc tttcatgatt tgtttaaaca aattttctta 7441 aaatttctga ggtttgttta tttcttttat cagtaaat //